Dilated cardiomyopathy impairs mitochondrial biogenesis and promotes inflammation in an age- and sex-dependent manner.

摘要: Dilated cardiomyopathy (DCM) belongs to the myocardial diseases associated with a severe impairment of cardiac function, but question how sex and age affect this pathology has not been fully explored. Impaired energy homeostasis, mitochondrial dysfunction, systemic inflammation are well-described phenomena aging. In study, we investigated if DCM affects these in sex- age-related manner. We analyzed expression antioxidant proteins inflammatory state heart tissue from younger older women men. A significant downregulation Sirt1 was detected patients. Sex-related differences were observed phosphorylation AMPK that only appeared males DCM, possibly due an alternative regulation mechanism. Furthermore, reduced several (TOM40, TIM23, Sirt3, SOD2) genes (cox1, nd4) old patients, suggesting greater effect than on alterations. Finally, increased markers older, failing hearts, stronger pro-inflammatory response men, observed. Together, findings indicate age- sex-related disturbance homeostasis occurs male individuals DCM.