Laboratory, clinical and therapeutic aspects of acquired hemophilia A

摘要: Acquired hemophilia A is a rare bleeding diathesis caused by autoantibodies directed against clotting factor VIII and associated with an increased morbidity mortality. This disease occurs most commonly in the elderly, although it may be variety of underlying pathological conditions, up to 50% reported cases remain idiopathic. In this review, we report present knowledge on important laboratory, diagnostic clinical aspects acquired A. Moreover, focus recent advances treatment disorder, which primarily aimed control episodes eradicate autoantibody production.