Malaria: Clinical and Epidemiological Aspects

摘要: The cycle of invasion, multiplication, and reinvasion takes place over 48 hours for P. falciparum, vivax, ovale; 72 malariae; 24 knowlesi. Although some degree anemia resulting from hemolysis infected red blood cells is an expected consequence symptomatic malaria infections, the pathogenesis severe malarial anemia, seen most commonly in falciparum disease, also present withP. multifactorial. Malaria during pregnancy carries a risk adverse birth outcomes such as spontaneous abortion, stillbirth, premature or intrauterine growth restriction, both which contribute to low weight, single important indicator infant mortality. With recent call elimination, more tools, including vaccines, can be anticipated near future. Host genetic factors that play roles epidemiology are summarized this chapter. new goal using vaccines elimination places increased emphasis on would completely prevent infection thus transmission by targeting pre-erythrocytic stages parasite life block directly generating immunity against sexual mosquito stages. Most based recombinant versions antigenic targets specific cycle, although DNA viral vector expression approaches have been used with limited success date. advanced vaccine circum sporozoite protein coats surface infectious sporozoites.