Mosaic Evolution of the Severe Acute Respiratory Syndrome Coronavirus

摘要: Severe acute respiratory syndrome (SARS) is a deadly form of pneumonia caused by novel coronavirus, viral family responsible for mild tract infections in wide variety animals including humans, pigs, cows, mice, cats, and birds. Analyses to date have been unable identify the precise origin SARS coronavirus. We used Bayesian, neighbor-joining, split decomposition phylogenetic techniques on virus replicase, surface spike, matrix, nucleocapsid proteins reveal evolutionary this recently emerging infectious agent. The analyses support mammalian-like replicase protein, an avian-like matrix proteins, mammalian-avian mosaic host-determining spike protein. A bootscan recombination analysis gene revealed high nucleotide identity between feline peritonitis throughout gene, except 200- base-pair region avian sequence. These data suggest possible past event parent viruses. This occurred near that has implicated be human receptor binding site may directly switch host coronavirus from humans.