The ‘Des Syndrome’: A prototype of Human Teratogenesis and Tumourigenesis by Xenoestrogens?

摘要: Diethylstilboestrol (DES), the first synthetic hormone, when antenatally prescribed to prevent spontaneous abortion, has been described in offspring cause a variety of congenital abnormalities female genital tract. In addition, with an estimated absolute risk 1:1000, it also causes clear cell adenocarcinoma (CCA) vagina and cervix young `DES-daughters’. Also neuroteratogenic effects have attributed DES, but psychopathology DES-exposed persons is shown here be largely iathrogenic, i.e., as consequence having disproportionately alarmed by its potential toxicity. With over 20,000 publications, DES one most studied compounds ever. Yet, many doubts persist on mechanisms action, whether or not may prevented some abortions, epidemiology causation CCA, how far affected humans through food-chain. Since no dose-effect relationship found humans, cannot excluded that could toxic at low doses, other less potent xenoestrogens would similar effects.