Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond

摘要: AbstractPlatelets are small anucleate blood cells generated from megakaryocytes in the bone marrow and cleared reticuloendothelial system. At site of vascular injury, platelet adhesion, activation aggregation constitute first wave hemostasis. Blood coagulation, which is initiated by intrinsic or extrinsic coagulation cascades, second Activated platelets can also provide negatively-charged surfaces that harbor factors markedly potentiate cell-based thrombin generation. Recently, deposition plasma fibronectin, likely other proteins, onto injured vessel wall has been identified as a new “protein hemostasis” may occur even earlier than hemostasis, accumulation. Although no experimental evidence currently exists, it conceivable contribute to this protein hemostasis releasing their granule fibronectin proteins facilitate fibronect...