Chapter 13 Role of the 6-Phosphomannosyl-Enzyme Receptor in Intracellular Transport and Adsorptive Pinocytosis of Lysosomal Enzymes
作者： William S. Sly , H. David Fischer , Alfonso Gonzalez-Noriega , Jeffrey H. Grubb , Marvin Natowicz
DOI: 10.1016/S0091-679X(08)61499-5
关键词: Mannose 6-phosphate receptor 、 Biology 、 Cell biology 、 Mannose 、 Secretion 、 Biochemistry 、 Receptor 、 Endoplasmic reticulum 、 Enzyme 、 Pinocytosis 、 Extracellular
摘要: Publisher Summary This chapter reviews the evidence that recognition marker on lysosomal enzymes contains mannose 6-phosphate (Man-6-P). The describes experiments suggest main function of Man-6-P in and its receptor membranes mammalian cells is to provide an intracellular transport system for segregating from other products endoplasmic reticulum (ER) transferring newly synthesized ER lysosomes. A model presented acid hydrolases proposes receive bind receptors, which collect into specialized vesicles bud off as primary lysosomes segregate are destined secretion. Similar receptors cell surface fibroblasts mediate adsorptive pinocytosis extracellular medium, though this pathway a minor one.
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