作者: Norma C. Alonzo , Bradley T. Hyman , G William Rebeck , Steven M. Greenberg
DOI: 10.1097/00005072-199804000-00008
关键词: Apolipoprotein E 、 Pathogenesis 、 Cerebral amyloid angiopathy 、 Central nervous system disease 、 Amyloidosis 、 Vascular disease 、 Asymptomatic 、 Amyloid 、 Pathology 、 Medicine
摘要: Cerebrovascular deposits of amyloid (cerebral angiopathy, or CAA) are generally asymptomatic, but in advanced cases, they can lead to vessel rupture and hemorrhage. The process progression CAA was studied by comparison postmortem brains with asymptomatic ("mild") the form disease associated hemorrhage ("severe CAA"). Cortical meningeal vessels were immunostained for beta-amyloid examined confocal microscopy systematic quantitative sampling. We focused on 2 parameters: proportion affected (a measure seeding vessels) amount per growth existing lesions). Surprisingly, there no difference between cortical mild severe (0.29 vs 0.32, p = 0.65), rather an increase area 40 amino acid (198.5 +/- 38.7 455.8 100.9 microm2/vessel, < 0.007). Increasing doses (from 0 1 copies) apolipoprotein E epsilon4 allele also greater without change within each class severity. These findings suggest that from reflects progressive accumulation previously seeded amyloid, this is selectively enhanced epsilon4.