The Role of the spv Genes in Salmonella Pathogenesis
作者： Donald G. Guiney , Joshua Fierer
关键词: Structural gene 、 Salmonella 、 Microbiology 、 Secretion 、 Phenotype 、 Phosphothreonine lyase activity 、 Biology 、 Virulence 、 Gene 、 Typhoid fever 、 Virology
摘要: Salmonella strains cause three main types of diseases in people: gastroenteritis, enteric (typhoid) fever, and non-typhoid extra-intestinal disease with bacteremia. Genetic analysis indicates that each clinical syndrome requires distinct sets virulence genes, isolates differ their constellation traits. The spv locus is strongly associated bacteremia, but are not present typhoid strains. region contains genes required for the phenotype mice: positive transcriptional regulator spvR two structural spvB spvC. SpvB SpvC translocated into host cell by pathogenicity island-2 type-three secretion system. prevents actin polymerization ADP-ribosylation monomers, while has phosphothreonine lyase activity been shown to inhibit MAP kinase signaling. exact mechanisms which act concert enhance still unclear. exhibits a cytotoxic effect on cells delayed death apoptosis following intracellular infection. Strains isolated from systemic infections immune compromised patients, particularly HIV usually carry locus, suggesting CD4 T control due positive. This association seen indicating pathogenesis immunology have fundamental differences
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sci-hub.se 参考文章(89)
Joshua Fierer, Invasive Salmonella dublin infections associated with drinking raw milk. Western Journal of Medicine. ,vol. 138, pp. 665- 669 ,(1983)
Robert H. Rubin, Marcia B. Goldberg, The spectrum of Salmonella infection. Infectious Disease Clinics of North America. ,vol. 2, pp. 571- 598 ,(1988) , 10.1016/S0891-5520(20)30212-9
D. G. Guiney, The role of host cell death in Salmonella infections. Current Topics in Microbiology and Immunology. ,vol. 289, pp. 131- 150 ,(2005) , 10.1007/3-540-27320-4_6
Lee-Ann H. Allen, Frank R. DeLeo, Annabelle Gallois, Satoshi Toyoshima, Kensuke Suzuki, William M. Nauseef, Transient Association of the Nicotinamide Adenine Dinucleotide Phosphate Oxidase Subunits p47phox and p67phox With Phagosomes in Neutrophils From Patients With X-Linked Chronic Granulomatous Disease Blood. ,vol. 93, pp. 3521- 3530 ,(1999) , 10.1182/BLOOD.V93.10.3521.410K21_3521_3530
Leigh A. Knodler, Olivia Steele-Mortimer, Taking possession: biogenesis of the Salmonella-containing vacuole. Traffic. ,vol. 4, pp. 587- 599 ,(2003) , 10.1034/J.1600-0854.2003.00118.X
Garth L. Abrahams, Petra Müller, Michael Hensel, Functional Dissection of SseF, a Type III Effector Protein Involved in Positioning the Salmonella-Containing Vacuole Traffic. ,vol. 7, pp. 950- 965 ,(2006) , 10.1111/J.1600-0854.2006.00454.X
J. el Benna, J.M. Ruedi, B.M. Babior, Cytosolic guanine nucleotide-binding protein Rac2 operates in vivo as a component of the neutrophil respiratory burst oxidase. Transfer of Rac2 and the cytosolic oxidase components p47phox and p67phox to the submembranous actin cytoskeleton during oxidase activation. Journal of Biological Chemistry. ,vol. 269, pp. 6729- 6734 ,(1994) , 10.1016/S0021-9258(17)37436-7
F C Fang, M Krause, C Roudier, J Fierer, D G Guiney, Growth regulation of a Salmonella plasmid gene essential for virulence. Journal of Bacteriology. ,vol. 173, pp. 6783- 6789 ,(1991) , 10.1128/JB.173.21.6783-6789.1991
Andrés Vazquez-Torres, Jessica Jones-Carson, Andreas J. Bäumler, Stanley Falkow, Raphael Valdivia, William Brown, Mysan Le, Ruth Berggren, W. Tony Parks, Ferric C. Fang, Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes Nature. ,vol. 401, pp. 804- 808 ,(1999) , 10.1038/44593
M Krause, F C Fang, D G Guiney, Regulation of plasmid virulence gene expression in Salmonella dublin involves an unusual operon structure. Journal of Bacteriology. ,vol. 174, pp. 4482- 4489 ,(1992) , 10.1128/JB.174.13.4482-4489.1992