Regioreversed addition of but-2-enyltributylstannane to aldehydes in the presence of aluminium chloride–propan-2-ol

作者: Yoshinori Yamamoto , Norihiko Maeda , Kazuhiro Maruyama

DOI: 10.1039/C39830000742

关键词: ChemistryMedicinal chemistryAluminium chlorideStereochemistryLewis acids and bases

摘要: The reaction of but-2-enyltributylstannane with certain aldehydes in the presence AlCl3–PriOH produces α-adduct (3) either predominantly or exclusively, while ordinary Lewis acids, such as TiCl4, SnCl4, and BF3·OEt2, affords γ-adduct (2) exclusively.

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