作者: Esteban Toro-Trujillo , E Garcia , Angel Alberto Garcia-Peña , OM Muñoz-Velandia , Alejandro Mariño
DOI: 10.1016/J.TRANSPROCEED.2018.08.041
关键词: Internal medicine 、 Acute cellular rejection 、 Repeated measures design 、 Heart graft 、 Incidence (epidemiology) 、 Calcineurin 、 Retrospective cohort study 、 Longitudinal model 、 Generalized estimating equation 、 Medicine
摘要: Abstract Introduction The acute cellular rejection is recognized as a factor related to the long-term viability of heart graft. We intend establish which factors are associated with during first year post transplant using longitudinal model repeated measures. Methods A retrospective cohort study was performed all patients who underwent between 2005–2018 at Hospital Universitario San Ignacio in Bogota, Colombia. In order determine development rejection, generalized estimating equation approach used, an interchangeable correlation structure. lowest value quasi-likelihood information criterion and P Results Fifty-five (49.3 ± 11.1 years old) were included. mortality month 16.3% accumulated 23.6%. incidence higher third after (79.9%); most them grade 1. cyclosporine levels out therapeutic range several periods evaluation (P Conclusions Using advanced modeling methodologies data we identified that calcineurin inhibitor (cyclosporin) 6 months follow-up age receptor.