TNF-238 polymorphism may predict bronchopulmonary dysplasia among preterm infants in the Egyptian population.
作者： Nasser A. Elhawary , Mohammed T. Tayeb , Shereen Abdel-Ghafar , Mona Rashad , Abdel-Aziz Alkhotani
DOI: 10.1002/PPUL.22748
关键词: Bronchopulmonary dysplasia 、 Genotype 、 Population 、 Birth weight 、 Confidence interval 、 Medicine 、 Dominance (genetics) 、 Pediatrics 、 Allele 、 Low birth weight
摘要: Summary. Bronchopulmonary dysplasia (BPD) remains as a major and increasing burden in Egypt. Rationale: To determine whether alleles of TNFa-238G > A affect the risk BPD or severity preterm infants Study Design: We prospectively genotyped 220 premature neonates (birth weight polymorphism was associated with twofold (OR ¼ 2.86; 95% confidence interval, 1.35–3.83). Despite dominance G allele Egyptian population, � 238A more common among (23%) than without (15%). The occurred less often mild (9%) severe (39%) moderate (52%). AA genotype 15% cases but none controls. Conclusion: TNFa 238G polymorphism— particularly presence an allele—should be evaluated biomarker to predict clinical outcome Even one copy this mutant appears sufficient influence disease. Pediatr Pulmonol.
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