Endoplasmic reticulum stress and apoptosis via PERK-eIF2α-CHOP signaling in the methamphetamine-induced chronic pulmonary injury
作者： Yu-han Gu , Yun Wang , Yang Bai , Ming Liu , Huai-liang Wang
DOI: 10.1016/J.ETAP.2017.01.003
关键词: CHOP 、 Endoplasmic reticulum 、 Pathology 、 Apoptosis 、 Internal medicine 、 Immunohistochemistry 、 Alveolar Epithelium 、 Endocrinology 、 Biology 、 ATF6 、 Epithelium 、 Methamphetamine
摘要: Methamphetamine (MA) leads to multiple organs lesions and apoptosis. The aim of this study is investigate if endoplasmic reticulum stress (ERS) - initiated apoptosis involved in the chronic pulmonary injury induced by MA. In study, rats were divided into a control group, methamphetamine 5mg/kg group 10mg/kg group. This found that protein level GRP78 higher M10 than PERK signaling relevant factors also activated. Morphological measurements showed BAX CHOP accumulated alveolar epithelium walls with damaged number alveoli decreased. findings ERS pathway are activated eventually lead Severe mediated cells as well decreasing numbers alveoli.
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