Harmful molecular mechanisms in sepsis

作者: Daniel Rittirsch , Michael A. Flierl , Peter A. Ward

DOI: 10.1038/NRI2402

关键词: Inflammatory mediatorInflammationImmunologySepsisBiologyIntensive care medicineBlood coagulation factorsBasic researchCytokines metabolismMolecular interactions

摘要: … In this Review, we highlight recent insights into the molecular interactions that occur during … various systems that contribute to sepsis pathogenesis in a complex 'inflammatory network'. …

参考文章(123)
Thomas Sautner, Michael Bergmann, Immunomodulatory effects of vasoactive catecholamines. Wiener Klinische Wochenschrift. ,vol. 114, pp. 752- 761 ,(2002)
John R. Klune, Rajeev Dhupar, Jon Cardinal, Timothy R. Billiar, Allan Tsung, HMGB1: endogenous danger signaling. Molecular Medicine. ,vol. 14, pp. 476- 484 ,(2008) , 10.2119/2008-00034.KLUNE
Jacqueline M L Stouthard, Marcel Levi, C Erik Hack, Cees H N Veenhof, Hans A Romijn, Hans P Sauerwein, Tom van der Poll, Interleukin-6 Stimulates Coagulation, not Fibrinolysis, in Humans Thrombosis and Haemostasis. ,vol. 76, pp. 738- 742 ,(1996) , 10.1055/S-0038-1650653
T. ITO, K. KAWAHARA, T. NAKAMURA, S. YAMADA, T. NAKAMURA, K. ABEYAMA, T. HASHIGUCHI, I. MARUYAMA, High‐mobility group box 1 protein promotes development of microvascular thrombosis in rats Journal of Thrombosis and Haemostasis. ,vol. 5, pp. 109- 116 ,(2007) , 10.1111/J.1538-7836.2006.02255.X
Yonggang Sha, Jaroslaw Zmijewski, Zhiwei Xu, Edward Abraham, HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines Journal of Immunology. ,vol. 180, pp. 2531- 2537 ,(2008) , 10.4049/JIMMUNOL.180.4.2531
G Goldberger, M.L. Thomas, B.F. Tack, J Williams, H.R. Colten, G.N. Abraham, NH2-terminal structure and cleavage of guinea pig pro-C3, the precursor of the third complement component. Journal of Biological Chemistry. ,vol. 256, pp. 12617- 12619 ,(1981) , 10.1016/S0021-9258(18)42933-X
Markus Huber-Lang, J. Vidya Sarma, Daniel Rittirsch, Heike Schreiber, Manfred Weiss, Michael Flierl, Ellen Younkin, Marion Schneider, Heidemarie Suger-Wiedeck, Florian Gebhard, Shannon D. McClintock, Thomas Neff, Firas Zetoune, Uwe Bruckner, Ren-Feng Guo, Peter N. Monk, Peter A. Ward, Changes in the Novel Orphan, C5a Receptor (C5L2), during Experimental Sepsis and Sepsis in Humans Journal of Immunology. ,vol. 174, pp. 1104- 1110 ,(2005) , 10.4049/JIMMUNOL.174.2.1104
K Fukudome, C T Esmon, Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. Journal of Biological Chemistry. ,vol. 269, pp. 26486- 26491 ,(1994) , 10.1016/S0021-9258(18)47220-1
Thierry Calandra, Bernd Echtenacher, Didier Le Roy, Jérôme Pugin, Christine N. Metz, Lothar Hültner, Didier Heumann, Daniela Männel, Richard Bucala, Michel P. Glauser, Protection from septic shock by neutralization of macrophage migration inhibitory factor Nature Medicine. ,vol. 6, pp. 164- 170 ,(2000) , 10.1038/72262
Markus Huber-Lang, Vidya J. Sarma, Kristina T. Lu, Stephanie R. McGuire, Vaishalee A. Padgaonkar, Ren-Feng Guo, Ellen M. Younkin, Robin G. Kunkel, Jiabing Ding, Richard Erickson, John T. Curnutte, Peter A. Ward, Role of C5a in Multiorgan Failure During Sepsis The Journal of Immunology. ,vol. 166, pp. 1193- 1199 ,(2001) , 10.4049/JIMMUNOL.166.2.1193