Falls and resulting fractures in Myotonic Dystrophy: Results from a multinational retrospective survey

摘要: Myotonic Dystrophy type 1 multisystem involvement leads to functional impairment with an increased risk of falling. This multinational study estimates the prevalence falls and fall-associated fractures. A web-based survey among disease-specific registries (Germany, UK The Netherlands) was carried out DM1 ambulant adults a total 573 responses retrieved. Results provided ratio estimation 30%-72% for 11%-17% associated There no significant difference between male female, but there fall-related fractures higher in women. Balance leg weakness were most commonly reported causes is based on voluntary retrospective naturally inherent limitations; however, sample size allows robust comparisons. estimated this cohort mean age 46 years compares previous healthy population over 65 age. These results suggest premature-ageing phenotype falling depending disease severity that, so far, might have been underestimated. may clinical implications development care guidelines when testing new interventions population.