Quantitative ultrasound and apoptotic death in the neonatal primate brain
作者： Ivan M. Rosado-Mendez , Kevin K. Noguchi , Laura Castañeda-Martinez , George Kirvassilis , Sophie H. Wang
DOI: 10.1016/J.NBD.2019.03.032
关键词: Pathology 、 Medicine 、 Anesthetic 、 Apoptosis 、 Sevoflurane 、 Ultrasound 、 Sedative 、 In vivo 、 Toxicity 、 Thalamus
摘要: Abstract Apoptosis is triggered in the developing mammalian brain by sedative, anesthetic or antiepileptic drugs during late gestation and early life. Whether human children are vulnerable to this toxicity mechanism remains unknown, as there no imaging techniques capture it. characterized distinct structural features, which affect way damaged tissue scatters ultrasound compared healthy tissue. We evaluated whether apoptosis, sevoflurane brains of neonatal rhesus macaques, can be detected using quantitative (QUS). Neonatal (n = 15) macaques underwent 5 h anesthesia. QUS images were obtained through sagittal suture at 0.5 6 h. Brains collected 8 h examined immunohistochemically analyze apoptotic neuronal oligodendroglial death. Significant apoptosis was white gray matter throughout brain, including thalamus. measured a change effective scatterer size (ESS), biomarker derived from echo signals with clinical scanners, after sevoflurane-anesthesia Although initial inclusion all measurements did not reveal significant correlation, when outliers excluded, ESS between pre- post-anesthesia correlated strongly proportionally severity report for first time vivo changes parameters, may reflect infant nonhuman primates. These findings suggest that enable studies infants following exposure anesthetics, antiepileptics other injury mechanisms.
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