One-time gene gun or intramuscular rabies DNA vaccination of non-human primates: comparison of neutralizing antibody responses and protection against rabies virus 1 year after vaccination.
作者： Donald L. Lodmell , Michael J. Parnell , John R. Bailey , Larry C. Ewalt , Cathleen A. Hanlon
DOI: 10.1016/S0264-410X(01)00392-9
关键词: Virology 、 Antibody titer 、 DNA vaccination 、 Rabies 、 Lyssavirus 、 Immunology 、 Biology 、 Vaccination 、 Gene gun 、 Neutralizing antibody 、 Rabies virus
摘要: We have previously shown that Macaca fascicularis (Cynomologus) monkeys receiving a primary and either one or two booster rabies DNA vaccinations are protected against virus. In this study, we determined whether had been vaccinated only once via gene gun intramuscularly (i.m.) with different concentrations of would be virus challenge. Neutralizing antibody responses were assayed for 1 year before the challenged. was detected at least 50 days earlier in as compared to i.m. animals. Prior viral challenge, all (6/6, 100%) animals, but 3/6 (50%) animals seroconverted. general, titers higher than There no correlation between concentration used vaccination, neutralizing elicited protection Seven after rapid strong anamnestic response 100% four monkeys. remained undetectable Overall, 60% (3/5) 87% (5/6) survived This study is first, our knowledge, show long-term non-human primates human pathogen using vaccination protocol did not include immunization.
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