Does thrombophilia testing help in the clinical management of patients
作者： Saskia Middeldorp , Astrid van Hylckama Vlieg
DOI: 10.1111/J.1365-2141.2008.07339.X
关键词: Thrombophilia 、 Surgery 、 Mass screening 、 Venous thrombosis 、 Thrombosis 、 Pulmonary embolism 、 Coagulopathy 、 Internal medicine 、 Factor V Leiden 、 Prothrombin G20210A 、 Medicine
摘要: Thrombophilia can be identified in about half of all patients presenting with venous thrombosis. Testing has increased tremendously for various indications, but whether the results such tests help clinical management not been settled. Here, we review most commonly tested thrombophilic abnormalities, i.e. protein C, S, and antithrombin deficiencies, F5 R506Q (factor V Leiden) F2 G20210A (prothrombin G20210A) mutations, elevated levels coagulation factor VIII, their association arterial thrombosis as well pregnancy complications. We conclude that testing hereditary thrombophilia generally does alter or Because only serves limited purpose this should performed on a routine basis.
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