An Approach to Estimate Between- and Within-Group Correlation Coefficients in Multicenter Studies: Plasma Carotenoids as Biomarkers of Intake of Fruits and Vegetables
作者： Pietro Ferrari , Wael K. Al-Delaimy , Nadia Slimani , Hendriek C. Boshuizen , Andrew Roddam
DOI: 10.1093/AJE/KWI242
关键词: Analysis of variance 、 European Prospective Investigation into Cancer and Nutrition 、 Lycopene 、 Regression analysis 、 Food science 、 Correlation coefficient 、 Intraclass correlation 、 Biology 、 Carotenoid 、 Correlation
摘要: In a multicenter study, the overall correlation between two variables can be broken down into within- and between-group reflecting associations at individual aggregate levels, respectively. A random-effects model is used to estimate variance components of nutrition-related coefficients. Using data from European Prospective Investigation Cancer Nutrition (EPIC), authors analyzed association levels three plasma carotenoids (alpha-carotene, beta-cryptoxanthin, lycopene) dietary intake items (total fruits, carrots, tomatoes), assessed through questionnaire single 24-hour recall measurements, in cross-sectional study involving 3,089 subjects nine countries. Intraclass coefficients were 0.178 for alpha-carotene, 0.216 0.299 lycopene. The higher than within-group all carotenoids. For beta-cryptoxanthin fruit intake, versus correlations 0.78 0.26 0.85 0.19 recall. Results indicate that variability exposure driven mainly by compared with variation biomarker perform fairly accurately discriminating population-level consumption fruits vegetables.
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