Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials

摘要: Combination antiretroviral therapy (cART) has transformed HIV from a deadly to chronic disease, but patients are still burdened with excess morbidity and mortality, long-term toxicities cART, stigmatization, insufficient access cART worldwide. Thus, cure for would have enormous impact on society as well the individual. As complexity mechanisms of persistence during being unraveled, new therapeutic targets eradication discovered. Substances that activate production in latently infected cells recently received much attention. By turning expression latent proviruses, reactivation strategies could contribute infection. Compounds currently or soon be tested clinical trials emphasized. The results these will provide important clues whether not reactivating become significant components HIV.