Autoregulation of histamine release via the histamine H3 receptor on mast cells in the rat skin.

摘要: The autoregulation of the histamine release via H3 receptor in periphery was studied vivo and vitro. Antidromic electrical stimulation sciatic nerve caused a significant increase subcutaneous perfusate rat hindpaw. (R)alpha-methylhistamine, specific agonist, significantly dose-dependently inhibited by antidromic at intravenous doses 0.25-2 mg/kg. Thioperamide (2 mg/kg, intraperitoneally), antagonist, prevented inhibitory effect (R)alpha-methylhistamine. Substance P perfusion (5-50 microM) also elicited histamine, inhibition (R)alpha-methylhistamine antagonism thioperamide were observed. substance from peritoneal mast cells vitro, reduced response to These data suggest that may have receptors, probably modulates its own through neurogenic inflammation.