Diffusion in two-component lipid membranes--a fluorescence correlation spectroscopy and monte carlo simulation study.

摘要: Using fluorescence correlation spectroscopy, calorimetry, and Monte Carlo simulations, we studied diffusion processes in two-component membranes close to the chain melting transition. The aim is describe complex behavior lipid systems which gel fluid domains coexist. Diffusion are significantly slower than membranes. mixed phase regions therefore expected be complex. Due statistical fluctuations gel-fluid domain patterns not uniform space time. No models for such available. In this article, both experimental theoretical, investigated DMPC-DSPC mixtures as a function of temperature composition. We then modeled spectroscopy experiment using simulations analyze process. It shown that yield very good description processes, predicted autocorrelation profiles superimposable with curves. believe study adds discussion on physical nature rafts found biomembranes.