Quantitative morphologic study of intimal thickening at the human carotid bifurcation: II. The compensatory enlargement response and the role of the intima in tensile support.

摘要: Abstract Arteries enlarge where intimal plaques form, tending to preserve lumen cross sectional area but causing an increase in mural tangential tension due the radius. To characterize compensatory enlargement process at carotid bifurcation and evaluate possible contribution of intima thickening tensile support during enlarging process, we assessed relationships among thickening, artery size estimated stress 9 sequential axial levels 42 human bifurcations obtained post-mortem examinations 36 adults with no clinical or anatomical evidence cerebrovascular disease. Right left were available for 6 patients. The arteries fixed under conditions controlled pressure distention histologic sections prepared 0.5 cm intervals. We determined vessel radius ( r ), thickness (IT), media (MT), (IA), (LuA) encompassed by internal elastic lamina (IELA), i.e. if there thickening. Although IT, IA greatest proximal sinus region, was a highly significant linear relationship between IELA each level; correlation coefficients ranged from 0.64 0.97 P 5 dyn/cm 2 (1 dyn=10 −5 N) maximum occurring sinus. When, however, total wall (IT + MT) used, TS similar all mean 6.5 ± 2.5 × 10 2, (range, 5.5 1.8 7.3 2.7 ) differences levels, including those little conclude that stages minimal moderate plaque formation bifurcation, (IELA) level increases IA, thereby preserving LuA. sum corresponds such remains normal level.