Postembryonic neural proliferation in the zebrafish forebrain and its relationship to prosomeric domains.

摘要: Large gaps of knowledge exist regarding postembryonic brain morphogenesis the zebrafish Danio rerio (Cyprinidae, Teleostei). The represents – together with frog (Xenopus), chick and mouse one four major models for genetic study early development. Here, we used normal silver-stained Bodian material immunohistochemical stained a monoclonal antibody against proliferating cell nuclear antigen (PCNA, cyclin) to morphogenetic appearance location proliferation zones between day 1 10, focussing on forebrain at 5 postfertilization. Our results directly demonstrate that dorsal telencephalic zone (i.e. pallium) extends consistent process eversion some distance laterally top telencephalon. subpallial consists ventral zones. preoptic region also includes In diencephalon proper, separate are present in habenula, periventricular masses thalamus, pretectum. More ventrocaudally, latter three massive appear be replaced each by thinner, but distinct Two them represent ventrocaudal continuations thalamus lie referred as posterior tubercular area adult teleostean neuroanatomy. third lies nucleus medial longitudinal fascicle. addition, several hypothalamic present. data largely agreement neuromeric model organization Puelles Rubenstein (1993), which is mostly based amniote data. Generally, understanding prosomeric origin prosencephalic may regarded pivotal their comparative interpretation.