Enhancement of benzalkonium chloride preservative activity in formulations containing an incompatible drug using amino acids having net positive charge

摘要: A formulation and method includes an acceptable drug, such as Prostaglandins, Flurbiprofen, Keterolac Tromethamine, Cetirizine HCl Indomethacin Bufrolin, which are interactive with benzalkonium chloride to form a precipitate along acting preservative amino acid having enough positive charge at the pH of and/or Tromethamine present in amount sufficient interfere interaction between drug order maintain activity chloride. Further, use Lysine, L-arginine, or Histidine is also useful reducing cytotoxicity formulation.