AMPK phosphorylation of raptor mediates a metabolic checkpoint.
作者： Dana M. Gwinn , David B. Shackelford , Daniel F. Egan , Maria M. Mihaylova , Annabelle Mery
DOI: 10.1016/J.MOLCEL.2008.03.003
关键词: AMPK 、 Biology 、 mTORC1 、 Cell growth 、 Phosphorylation 、 Cell biology 、 PI3K/AKT/mTOR pathway 、 Cell cycle 、 Autophagy-Related Protein-1 Homolog 、 AMP-activated protein kinase
摘要: … substrates of AMPK that mediate its effects on growth control. We report here that AMPK directly … The phosphorylation of raptor by AMPK is required for the inhibition of mTORC1 and cell-…
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