Azole nucleosides and use as inhibitors of rna and dna varial polymerases
作者： Jeffrey B. Arterburn , Colleen B. Jonsson , William B. Parker
DOI:
关键词: Stereochemistry 、 Alkyl 、 RNA 、 Polymerase 、 DNA 、 Azole 、 Aryl 、 Chemistry 、 DNA polymerase 、 Organic chemistry 、 Prodrug
摘要: Azole nucleosides represented by the formulae (I) and (II); wherein A = C or N B X H; C1-C6 alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclo, halogen such as F, C1, Br I; OH, NH2, NH-(C1-C6 heterocyclo); Z Cl, Br, heterocyclo; E= (CH2)HONHR1; n is an integer from 0-6 more typically 0-3; R1= aryl each of W, Y, R individually selected group consisting O, Oalkyl, Oaryl, provided that at least one other than H both W Y together can be =O; D Fl H;pharmaceutically acceptable salts thereof, prodrugs thereof mixtures are provided. Compounds this disclosure useful inhibitors viral RNA DNA polymerases as, but not limited to, Influenza, Hantaan Virus, Crimean Congo hemorrhagic fever virus, hepatitis B, C, Polio, Coxsackie Rhino, Echo, orthopoxvirus (small pox), HIV, Ebola, West Nile virus polymerases; especially orthopoxvirus, B.
lens.org 参考文章(26)
Oscar L. Acevedo, Phillip Dan Cook, Martin G. Dunkel, Pyrimidine nucleoside compounds and oligonucleoside compounds containing same ,(1994)
Raymond G. Lovey, Jinping McCormick, Ashit K. Ganguly, Anil K. Saksena, Viyyoor M. Girijavallabhan, Frank Bennett, 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon ,(1999)
Phillip Dan Cook, Thomas Bruice, Charles John Guinosso, Andrew Mamoru Kawasaki, Richard Griffey, None, Compositions and methods for modulating RNA ,(1993)
K. Raja Reddy, Mark D. Erion, Edward D. Robinson, Novel-prodrugs for phosphorus-containing compounds ,(1999)
Lieven J. Stuyver, Compounds for the treatment of flaviviridae infections ,(2004)
Clinton E. Browne, David A. Bullough, Ernest K. Metzner, Harry E. Gruber, Kevin M. Mullane, Bheemarao G. Ugarkar, Aica riboside analogs ,(1991)
Sergey G. Lokhov, Robert O. Dempcy, Yevgeniy S. Belousov, Alexei Vorobiev, Single nucleotide polymorphism analysis of highly polymorphic target sequences ,(2004)
Glenn Hoke, C. Frank Bennett, Nicholas M. Dean, Phillip Dan Cook, Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C ,(1997)
Andrew Kawasaki, Oscar Leobardo Acevedo, Kandasamy Ramasamy, Charles John Guinosso, Phillip Dan Cook, David J. Ecker, Compound for detecting and modulating RNA activity and gene expression ,(1995)
Muthiah Manoharan, Phillip Dan Cook, Clarence Frank Bennett, Derivatized oligonucleotides having improved uptake and other properties ,(1992)