Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels
作者： Jiandong Han , Xingyu Zhao , Weiguo Xu , Wei Wang , Yuping Han
DOI: 10.3390/MOLECULES23051017
关键词: Polymerization 、 Chemistry 、 Surface modification 、 Biodegradation 、 Copolymer 、 Chemical engineering 、 Degradation (geology) 、 Self-healing hydrogels 、 Drug carrier 、 Biocompatibility
摘要: Thermosensitive gels are commonly used as drug carriers in medical fields, mainly due to their convenient processing and easy functionalization. However, overall performance has been severely affected by unsatisfying biocompatibility biodegradability. To this end, we synthesized poly(l-alanine) (PLAla)-based thermosensitive hydrogels with different degrees of polymerization ring-opening polymerization. The obtained mPEG45−PLAla copolymers showed distinct transition temperatures degradation abilities. It was found that slight changes the length hydrophobic side groups had a decisive effect on gelation behavior polypeptide hydrogel. Longer ends led lower temperature gel at same concentration, which implied better capability. rapid gelling, enhanced biocompatibility, degradability. Therefore, hydrogel is promising material for biomedical application.
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