What Is Necessary for Proof? Is 95% Sure Unrealistic?
作者： Robert L. Wears
DOI: 10.1001/JAMA.1994.03510280034022
关键词: Clinical study design 、 Risk analysis (engineering) 、 Medicine
摘要: To the Editor. —The discussion by Dr Eddy 1 of what is needed for evidence to be "sufficient" when evaluating medical treatments deserves further exploration. Even if we can agree on appropriate end points, study designs, and use expert knowledge, question how certain must that treatment A beneficial compared with B still
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