作者: Sage Eh , Vernon Rb
DOI:
关键词: Angiogenesis 、 In vivo 、 Morphogenesis 、 Proteolysis 、 Cell biology 、 Endothelial stem cell 、 Fibronectin 、 Type I collagen 、 Extracellular matrix 、 Medicine
摘要: DEFINITION Angiogenesis is broadly defined as the growth of new capillaries from extant vessels and constitutes a major part developmental morphogenesis, response to injury pathogenesis. Two regulatory pathways are proposed by which angiogenesis thought proceed. PROLIFERATIVE PATHWAY The proliferative pathway depends on various cytokines other factors that both stimulate inhibit proliferation endothelial cells. One these components, secreted protein acidic rich in cysteine (SPARC), might function at several levels control progression neovessels. Proteolysis this component (e.g. plasmin) results release peptides containing sequence Gly-His-Lys, angiogenic vitro vivo. At later stages when cell ceases, intact exert its known inhibitory effect cycle progression. MORPHOGENETIC morphogenetic synthesis assembly fibrillar type I collagen, can be used template for migration lumen formation. Endothelial cells interact with substrates collagen form networks based establishment traction centers. These planar cellular networks, some respects, resemble developing vasculature CONCLUSION An understanding how morphogenesis controlled during vascular likely reconcile models respect regulate dynamic process.