The restorative effect of erythropoietic stimulation upon the sublethally irradiated (SLI) hematopoietic stem cell and/or its progeny.

摘要: Bone marrow cells from sublethally irradiated donor mice injected into supralethally (1000 R) recipients produced not only many fewer spleen colonies but erythrocytic (E) in relation to the number of granulocytic (G) than did unirradiated similar recipients. This reversal E:G ratio was partially or completely restored by a strong erythropoietic stimulus recipients, whether endogenous, (induced anemia) exogenous (injected purified EP). Such large increase total colony numbers all experiments. An unexpected result major and megakaryocytic erythropoietically stimulated It concluded that sublethal irradiation either revealed subpopulation potential forming whose cell cycle slow temporarily arrested. The added EP (and/or related substances) proposed have overridden induced repair radiation defect, small normally undetectable population requiring high levels stimulant induce cycling. expression their progeny as colonies, differentiative type depended upon kind hematpoietic inducing microenvironment which they had lodged.