Liver injury following halothane anesthesia in phenobarbital-pretreated rats.

摘要: Abstract Linear foci of centrolobular necrosis on the posterior aspect liver were consistently produced by 5 hr anesthesia with 0.85% halothane in young male rats pretreated phenobarbital (PBT: 1 g/l. drinking water) for 30 days. Microsomes isolated from livers these animals immediately upon completion had elevated lipid-conjugated diene and decreased cytochrome P-450 content 14 C-glycine incorporation into protein vivo . Lipid-conjugated dienes glycine incorporation, but not P-450, returned to pre-anesthesia levels within 2 hr. None alterations evident after saline-pretreated (0.23 g NaCl/l. water). Aside persistence animals, did occur repeated at 48-hr intervals, nor was hepatic as evident, although recovery times increased significantly. These findings indicate that metabolites are directly hepatotoxic 2-day intervals decreases its effect—presumably interfering metabolism toxic endoplasmic reticulum. Similar morphologic lesions can also be PBT-pretreated minute doses CCl 4