Expression of Oncogene Products HER2/Neu and Ras and Fibrosis-Related Growth Factors bFGF, TGF-β, and PDGF in Bile from Biliary Malignancies and Inflammatory Disorders
作者： Wu-Chou Su , Shu-Chu Shiesh , Hsiao-Sheng Liu , Chiung-Yu Chen , Nan-Haw Chow
关键词: HER2/neu 、 Pathogenesis 、 Platelet-derived growth factor 、 Cancer research 、 Hepatology 、 Gallbladder 、 Biliary tract 、 Bile duct 、 Pathology 、 Biology 、 Internal medicine 、 Gene mutation
摘要: The expression of several growth factors and K-ras gene mutation in bile were studied to better understand the pathogenesis improve early diagnosis duct cancers. Bile samples collected from 12 cholangiocarcinomas (CLC), 10 ampullary cancers (APC), 3 gallbladder (GBC), 7 pancreatic (PNC), 9 biliary tract infection (BTI), 8 stone disease (ST), 5 normal controls (NC). highest mean value TGF-β was patients with BTI; levels bFGF PDGF CLC, APC CLC had higher HER2/Neu than other groups. In bile, a codon found 6 (83%) cases by PCR-RFLP method. results suggest overexpression bFGF, PDGF, presence are important for carcinogenesis cancers, detection above abnormalities is helpful diagnosis.
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