Mechanisms of Cell Death in Heart Disease
作者： Klitos Konstantinidis , Russell S. Whelan , Richard N. Kitsis
DOI: 10.1161/ATVBAHA.111.224915
关键词: Apoptosis 、 Autophagy 、 Biology 、 Programmed cell death 、 Heart failure 、 Immunology 、 Mitochondrial permeability transition pore 、 Necrosis 、 Myocardial infarction 、 Heart disease 、 Bioinformatics
摘要: The major cardiac syndromes, myocardial infarction and heart failure, are responsible for a large portion of deaths worldwide. Genetic pharmacological manipulations indicate that cell death is an important component in the pathogenesis both diseases. Cells die primarily by apoptosis or necrosis, autophagy has been associated with death. Apoptosis long recognized as highly regulated process. Recent data significant subset necrotic also programmed. In review, we discuss molecular mechanisms underlie these forms their interconnections. possibility raised small molecules aimed at inhibiting may provide novel therapies common lethal syndromes.
sci-hub.se 参考文章(133)
M Crompton, A Costi, L Hayat, Evidence for the presence of a reversible Ca2+-dependent pore activated by oxidative stress in heart mitochondria Biochemical Journal. ,vol. 245, pp. 915- 918 ,(1987) , 10.1042/BJ2450915
P. Anversa, J. Kajstura, G. Olivetti, Wei Cheng, S. Krajewski, K. Reiss, J. C. Reed, E. H. Sonnenblick, W. A. Clark, Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Laboratory Investigation. ,vol. 74, pp. 86- 107 ,(1996)
Lily Y Li, Xu Luo, Xiaodong Wang, None, Endonuclease G is an apoptotic DNase when released from mitochondria Nature. ,vol. 412, pp. 95- 99 ,(2001) , 10.1038/35083620
Nils Holler, Rossana Zaru, Olivier Micheau, Margot Thome, Antoine Attinger, Salvatore Valitutti, Jean-Luc Bodmer, Pascal Schneider, Brian Seed, Jürg Tschopp, Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nature Immunology. ,vol. 1, pp. 489- 495 ,(2000) , 10.1038/82732
M Crompton, A Costi, H Ellinger, Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochemical Journal. ,vol. 255, pp. 357- 360 ,(1988)
Nika N Danial, Stanley J Korsmeyer, Cell Death: Critical Control Points Cell. ,vol. 116, pp. 205- 219 ,(2004) , 10.1016/S0092-8674(04)00046-7
F. C. Kischkel, S. Hellbardt, I. Behrmann, M. Germer, M. Pawlita, P. H. Krammer, M. E. Peter, Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. The EMBO Journal. ,vol. 14, pp. 5579- 5588 ,(1995) , 10.1002/J.1460-2075.1995.TB00245.X
Zhongyi Chen, Chu Chang Chua, Ye-Shih Ho, Ronald C. Hamdy, Balvin H. L. Chua, Overexpression of Bcl-2 attenuates apoptosis and protects against myocardial I/R injury in transgenic mice. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 280, ,(2001) , 10.1152/AJPHEART.2001.280.5.H2313
Sebastiano Sciarretta, Peiyong Zhai, Dan Shao, Yasuhiro Maejima, Jeffrey Robbins, Massimo Volpe, Gianluigi Condorelli, Junichi Sadoshima, Rheb is a Critical Regulator of Autophagy during Myocardial Ischemia: Pathophysiological Implications in Obesity and Metabolic Syndrome Circulation. ,vol. 125, pp. 1134- 1146 ,(2012) , 10.1161/CIRCULATIONAHA.111.078212
Hirohito Yamaguchi, Hong-Gang Wang, CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells Journal of Biological Chemistry. ,vol. 279, pp. 45495- 45502 ,(2004) , 10.1074/JBC.M406933200