A compact, portable, re-configurable, and automated system for on-demand pharmaceutical tablet manufacturing.

摘要: Abstract Due to the complex nature of pharmaceutical supply chain, industry faces several major challenges when it comes ensuring an adequate quality drug products. These are not only causes chain disruptions and financial loss, but can also prevent underserved remote areas from receiving life-saving drugs. As a preliminary demonstration mitigate all these challenges, at MIT we have developed active ingredients manufacturing in miniature platform. However, final oral solid dosage as tablets substances had been demonstrated. In this study, compact, portable, re-configurable, automated tablet system, roughly size North American household oven, [72.4 cm (length) × 53.3 cm (width) × 134.6 cm (height)] was designed, built This system is able manufacture on-demand crystals on scale hundreds thousands per day. Ibuprofen Diazepam, each having different loading, were manufactured using meet U.S. Pharmacopeia standards. We foresee flexible, miniature, plug-and-play solids advancing ready-to-use pharmaceuticals enabling future treatment human diseases point-of-care.