Cardiovascular disease-related mortality and factors associated with cardiovascular events in the TREAT Asia HIV Observational Database (TAHOD)

摘要: OBJECTIVES With aging of the HIV-positive population, cardiovascular disease (CVD) increasingly contributes to morbidity and mortality. We investigated CVD-related other causes death (CODs) factors associated with CVD in a multi-country Asian cohort. METHODS Patient data from 2003-2017 were obtained Therapeutics, Research, Education AIDS Training Asia (TREAT Asia) HIV Observational Database (TAHOD). included patients on antiretroviral therapy (ART) > 1 day follow-up. Cumulative incidences plotted for CVD-related, AIDS-related, non-AIDS-related, unknown CODs, any (i.e. fatal nonfatal). Competing risk regression was used assess CVD. RESULTS Of 8069 median follow-up 7.3 years [interquartile range (IQR) 4.4-10.7 years], 378 died [incidence rate (IR) 6.2 per 1000 person-years (PY)], this total 22 deaths (IR 0.36 PY). Factors significantly event 2.2 PY) older age [sub-hazard ratio (sHR) 2.21; 95% confidence interval (CI) 1.36-3.58 41-50 years; sHR 5.52; CI 3.43-8.91 ≥ 51 years, compared < 40 high blood pressure (sHR 1.62; 1.04-2.52), cholesterol 1.89; 1.27-2.82), triglycerides 1.55; 1.02-2.37) body mass index (BMI) 1.66; 1.12-2.46). crude IRs lower later ART initiation period middle- upper middle-income countries. CONCLUSIONS The development nonfatal events our cohort age, treatable such as pressure, triglycerides, BMI. Lower rates countries may indicate under-diagnosis Asian-Pacific resource-limited settings.