Shear mechanosensing drives tendon adaptation
作者： Spencer P. Lake , Jeremy D. Eekhoff , Leanne E. Iannucci
DOI: 10.1038/S41551-021-00724-X
关键词: Jumping 、 PIEZO1 、 Calcium 、 Shear (sheet metal) 、 Shear stress 、 Tendon stiffness 、 Materials science 、 Tendon 、 Biophysics 、 Mechanosensitive ion channel
摘要: In tendon cells under shear stress, the induction of an influx calcium by mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases stiffness and potentially improves jumping performance.
nature.com
sci-hub.st 参考文章(14)
Sanjeev S Ranade, Zhaozhu Qiu, Seung-Hyun Woo, Sung Sik Hur, Swetha E Murthy, Stuart M Cahalan, Jie Xu, Jayanti Mathur, Michael Bandell, Bertrand Coste, Yi-Shuan J Li, Shu Chien, Ardem Patapoutian, None, Piezo1, a mechanically activated ion channel, is required for vascular development in mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 10347- 10352 ,(2014) , 10.1073/PNAS.1409233111
B. Coste, J. Mathur, M. Schmidt, T. J. Earley, S. Ranade, M. J. Petrus, A. E. Dubin, A. Patapoutian, Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels Science. ,vol. 330, pp. 55- 60 ,(2010) , 10.1126/SCIENCE.1193270
Spencer E. Szczesny, Dawn M. Elliott, Interfibrillar shear stress is the loading mechanism of collagen fibrils in tendon. Acta Biomaterialia. ,vol. 10, pp. 2582- 2590 ,(2014) , 10.1016/J.ACTBIO.2014.01.032
Michael Lavagnino, Steven P. Arnoczky, Tao Tian, Zachary Vaupel, Effect of amplitude and frequency of cyclic tensile strain on the inhibition of MMP-1 mRNA expression in tendon cells: An in vitro study Connective Tissue Research. ,vol. 44, pp. 181- 187 ,(2003) , 10.1080/03008200390215881
Steven P. Arnoczky, Michael Lavagnino, Joanne H. Whallon, Amardeep Hoonjan, In situ cell nucleus deformation in tendons under tensile load; a morphological analysis using confocal laser microscopy Journal of Orthopaedic Research. ,vol. 20, pp. 29- 35 ,(2002) , 10.1016/S0736-0266(01)00080-8
Allen J Bailey, Robert Gordon Paul, Lynda Knott, Mechanisms of maturation and ageing of collagen Mechanisms of Ageing and Development. ,vol. 106, pp. 1- 56 ,(1998) , 10.1016/S0047-6374(98)00119-5
Christian Couppé, René B Svensson, Jean-Francois Grosset, Vuokko Kovanen, Rie H Nielsen, Morten R Olsen, Jytte O Larsen, Stephan FE Praet, Dorthe Skovgaard, Mette Hansen, Per Aagaard, Michael Kjaer, S Peter Magnusson, None, Life-long endurance running is associated with reduced glycation and mechanical stress in connective tissue Age. ,vol. 36, pp. 9665- 9665 ,(2014) , 10.1007/S11357-014-9665-9
R. F. Ker, M. B. Bennett, S. R. Bibby, R. C. Kester, R. McN. Alexander, The spring in the arch of the human foot Nature. ,vol. 325, pp. 147- 149 ,(1987) , 10.1038/325147A0
A. Arampatzis, K. Karamanidis, K. Albracht, Adaptational responses of the human Achilles tendon by modulation of the applied cyclic strain magnitude. The Journal of Experimental Biology. ,vol. 210, pp. 2743- 2753 ,(2007) , 10.1242/JEB.003814
Joanne Garvin, Jie Qi, Melissa Maloney, Albert J. Banes, Novel system for engineering bioartificial tendons and application of mechanical load. Tissue Engineering. ,vol. 9, pp. 967- 979 ,(2003) , 10.1089/107632703322495619