The cardiomyocyte cell cycle in hypertrophy, tissue homeostasis, and regeneration.

摘要: Mammalian cardiomyocytes withdraw from the cell cycle shortly after birth. Although adult heart is unable to regenerate, numerous reports have shown that exhibit a dynamic range of activity under various physiological and pathological conditions. Reason consequence cardiomyocyte remain unclear led number misconceptions. Understanding scenarios in which cycling happens may promote new perspectives on differentiated state cardiomyocytes, treatments for hypertrophy, regeneration cancer therapy. In this review we discuss result aging disease studies manipulating cardiac regeneration. addition, focus differentiation, exit, relationship between ploidy regenerative potential. Finally, provide observations further advance goal inducing mammalian through proliferation.