Mirror movements in X-linked Kallmann's syndrome. II. A PET study

作者: M Krams , R Quinton , MJ Mayston , LM Harrison , Raymond J Dolan

DOI: 10.1093/BRAIN/120.7.1217

关键词: ElectromyographyPrimary motor cortexPsychologyVoluntary musculoskeletal movementAudiologyIndex fingerSomatosensory systemKallmann syndromeKallmann's syndromeNeuroscienceMotor cortex

摘要: To investigate the mechanism of mirror movements seen in X-linked Kallmann's syndrome, we measured changes regional cerebral blood flow with H2 15O-PET. We studied six right-handed Kallmann male subjects and matched, control during an externally paced finger opposition task. The analyses were done both on a single subject group basis. showed strong primary motor cortex (M1) activation contralateral to voluntarily moved hand, but there was also significant degree M1 ipsilateral i.e. mirroring hand. However, when comparing activation, hand significantly stronger. In controls, increases rCBF voluntary movement either hand; small found two out normal they their left second experiment it shown that, subjects, passive right resulted that similar made This suggests, does not prove, may be due sensory feedback from involuntarily

参考文章(5)
R Quinton, V M Duke, P A de Zoysa, A D Platts, A Valentine, B Kendall, S Pickman, J M Kirk, G M Besser, H S Jacobs, P M Bouloux, The Neuroradiology of Kallmann's Syndrome: A Genotypic and Phenotypic Analysis The Journal of Clinical Endocrinology and Metabolism. ,vol. 81, pp. 3010- 3017 ,(1996) , 10.1210/JCEM.81.8.8768867
P D Cheney, E E Fetz, Corticomotoneuronal cells contribute to long-latency stretch reflexes in the rhesus monkey. The Journal of Physiology. ,vol. 349, pp. 249- 272 ,(1984) , 10.1113/JPHYSIOL.1984.SP015155
Karl. J. Friston, J. Ashburner, C. D. Frith, J.-B. Poline, J. D. Heather, R. S. J. Frackowiak, Spatial registration and normalization of images Human Brain Mapping. ,vol. 3, pp. 165- 189 ,(1995) , 10.1002/HBM.460030303
A.C. Evans, D.L. Collins, S.R. Mills, E.D. Brown, R.L. Kelly, T.M. Peters, 3D statistical neuroanatomical models from 305 MRI volumes nuclear science symposium and medical imaging conference. pp. 1813- 1817 ,(1993) , 10.1109/NSSMIC.1993.373602