作者: Caroline O. S. Savage , Gillian Gaskin , Charles D. Pusey , Jeremy D. Pearson
DOI: 10.1007/978-1-4757-9182-2_20
关键词: Molecular biology 、 Microscopic Polyarteritis 、 Hypochlorous acid 、 Complement-dependent cytotoxicity 、 Immunology 、 Hydrogen peroxide 、 Autoantibody 、 Myeloperoxidase 、 Chemistry
摘要: Myeloperoxidase (MPO) and proteinase-3 (Pr-3) can bind to vascular endothelial cells (EC) are available for recognition by autoantibodies present in P-ANCA or C-ANCA containing sera, respectively. The bound MPO also retains its enzymic functions effectively interacts with hydrogen peroxide mediate detachment of from their substratum. EC MPO-anti-MPO complexes contribute the complement-dependent injury demonstrated some sera.