Low temperature plasma biomedicine: A tutorial reviewa)

作者: David B. Graves

DOI: 10.1063/1.4892534

关键词: Biomedical equipmentBiomedicinePhysicsCancer treatmentIntensive care medicineLow temperature plasmaPatient treatment

摘要: Gas discharge plasmas formed at atmospheric pressure and near room temperature have recently been shown to be potentially useful for surface wound sterilization, antisepsis, bleeding cessation, healing, cancer treatment, among other biomedical applications. This tutorial review summarizes the field, stressing likely role of reactive oxygen nitrogen species created in these as biologically therapeutically active agents. Reactive species, including radicals non-radical compounds, are generated naturally within body now understood essential normal biological functions. These known agents existing therapies infection control, treatment. But they also observed elevated levels persons with many diseases associated aging. The physical chemical complexity plasma medical devices their biochemical effects makes development safe, effective procedures a challenge, but encouragingly rapid progress has reported around world last several years.

参考文章(54)
CARROLL E. CROSS, Oxygen Radicals and Human Disease Annals of Internal Medicine. ,vol. 107, pp. 526- 545 ,(1987) , 10.7326/0003-4819-107-4-526
Andrea Bellavia, Susanna C Larsson, Matteo Bottai, Alicja Wolk, Nicola Orsini, Fruit and vegetable consumption and all-cause mortality: a dose-response analysis The American Journal of Clinical Nutrition. ,vol. 98, pp. 454- 459 ,(2013) , 10.3945/AJCN.112.056119
Ryan M. Walk, Jason A. Snyder, Priya Srinivasan, Jacob Kirsch, Stephanie O. Diaz, Felix C. Blanco, Alexey Shashurin, Michael Keidar, Anthony D. Sandler, Cold atmospheric plasma for the ablative treatment of neuroblastoma Journal of Pediatric Surgery. ,vol. 48, pp. 67- 73 ,(2013) , 10.1016/J.JPEDSURG.2012.10.020
Helene Pelicano, Dennis Carney, Peng Huang, ROS stress in cancer cells and therapeutic implications. Drug Resistance Updates. ,vol. 7, pp. 97- 110 ,(2004) , 10.1016/J.DRUP.2004.01.004
A. L. Groeger, B. A. Freeman, Signaling Actions of Electrophiles: Anti-inflammatory Therapeutic Candidates Molecular Interventions. ,vol. 10, pp. 39- 50 ,(2010) , 10.1124/MI.10.1.7
Marc Vandamme, Eric Robert, Sabrina Pesnel, Emerson Barbosa, Sébastien Dozias, Julien Sobilo, Stéphanie Lerondel, Alain Le Pape, Jean-Michel Pouvesle, Antitumor Effect of Plasma Treatment on U87 Glioma Xenografts: Preliminary Results Plasma Processes and Polymers. ,vol. 7, pp. 264- 273 ,(2010) , 10.1002/PPAP.200900080
G. Isbary, G. Morfill, H.U. Schmidt, M. Georgi, K. Ramrath, J. Heinlin, S. Karrer, M. Landthaler, T. Shimizu, B. Steffes, W. Bunk, R. Monetti, J.L. Zimmermann, R. Pompl, W. Stolz, A first prospective randomized controlled trial to decrease bacterial load using cold atmospheric argon plasma on chronic wounds in patients. British Journal of Dermatology. ,vol. 163, pp. 78- 82 ,(2010) , 10.1111/J.1365-2133.2010.09744.X
YuBin Xian, Peng Zhang, XinPei Lu, XueKai Pei, ShuQun Wu, Qing Xiong, Kostya (Ken) Ostrikov, From short pulses to short breaks: exotic plasma bullets via residual electron control Scientific Reports. ,vol. 3, pp. 1599- 1599 ,(2013) , 10.1038/SREP01599
D Ellerweg, J Benedikt, A von Keudell, N Knake, V Schulz-von der Gathen, Characterization of the effluent of a He/O 2 microscale atmospheric pressure plasma jet by quantitative molecular beam mass spectrometry New Journal of Physics. ,vol. 12, pp. 013021- ,(2010) , 10.1088/1367-2630/12/1/013021
Fatma Vatansever, Wanessa CMA de Melo, Pinar Avci, Daniela Vecchio, Magesh Sadasivam, Asheesh Gupta, Rakkiyappan Chandran, Mahdi Karimi, Nivaldo A Parizotto, Rui Yin, George P Tegos, Michael R Hamblin, None, Antimicrobial strategies centered around reactive oxygen species - bactericidal antibiotics, photodynamic therapy and beyond Fems Microbiology Reviews. ,vol. 37, pp. 955- 989 ,(2013) , 10.1111/1574-6976.12026