Computational and Modeling Aspects of RTK Networks

摘要: Receptor tyrosine kinases, along with G protein-coupled receptors and the group of cytokine receptors, transmit a great majority extracellular cues to cytoplasm nucleus target cells. Here we focus on one subgroup receptor whose prototype is epidermal growth factor (EGFR). Due ligand-induced homo- heterodimerization by EGFR (also called ERBB1) other family members, signals are processed layered signaling network, which generates complex, time-dependent output. Mass-action models well describe emergent behavior but their establishment requires detailed experimental data. For example, mass-action incorporate feedback regulatory loops explain ligand-specific rewiring as emergence ultrasensitivity. Other computational employed when volume data limited. Both more abstractive help uncover fragile nodes amenable for therapeutic intervention. Likewise, co-option network’s robustness disease states might be modeled understand sensitivity, resistance, drugs targeting signal transduction ERBB related networks.