The Antiproteinuric Effect of Angiotensin-Converting-Enzyme Inhibitors in Human Renal Disease

摘要: Many renal diseases are accompanied by an excess loss of plasma proteins in the urinary space. As such proteinuria has been successfully used as a tool both to detect presence disease and evaluate success therapeutic interventions on activity. The quantity quality protein leakage may some cases distinguish between different underlying causes disease. In case minimalchange disease, is usually excreted considerable quantities, largely confined albumin, whereas specific tubular rather small consisting mainly low-molecular-weight proteins. However, general, does not differentiate multiple insults, suggesting more or less common cause pathway loss. Indeed, be discriminating properties glomerular filtration barrier for macromolecules. health, this prevents space at least two selective mechanisms. Firstly, pores limited size, hindering passage macromolecules larger than ≈55 Angstrom (size selectivity). Secondly, negative charges embedded prevent main negatively-charged protein, albumin (charge Furthermore, proximal reabsorption those that escape these restrictive properties.