Molecular cloning of vitellogenin gene promoters and in vitro and in vivo transcription profiles following estradiol-17β administration in the cutthroat trout.
作者： Yuji Mushirobira , Osamu Nishimiya , Jun Nagata , Takashi Todo , Akihiko Hara
DOI: 10.1016/J.YGCEN.2018.06.017
关键词: Cell biology 、 Regulation of gene expression 、 Reporter gene 、 Promoter 、 Hormone response element 、 Vitellogenin 、 Biology 、 Gene expression 、 Transcriptional regulation 、 Transcription (biology)
摘要: Transcription of vitellogenin (vtg) genes are initiated when estradiol-17β (E2)-estrogen receptor (ER) complexes bind estrogen response elements (ERE) located in the gene promoter region. Transcriptional regulation dual vtg subtypes (major salmonid A-type vtg: vtgAs; minor C-type vtgC) by E2 was investigated under co-expression a potential major transcriptional factor, erα1, cutthroat trout. Two forms trout vtgAs promoters (1 and 2) one vtgC were sequenced. These structurally differ based on number EREs present. The 1 exhibited highest maximal activity vitro reporter assays. concentration that induces 50% (half-maximal effective concentrations, EC50) similar among all also to EC50 administered induce transcription vivo. This study revealed difference properties multiple for first time species, providing basis understand mechanisms underlying vitellogenesis via expression.
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