Perfluoroalkyl substances, bone density, and cardio-metabolic risk factors in obese 8-12 year old children: A pilot study.

摘要: Abstract Background and objective Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS), perfluorononanoic (PFNA), have been associated with adverse bone, metabolic changes in adults. However association of PFASs bone health children is understudied. Considering their role as endocrine disruptors, we examined relationships four children. Methods In a cross sectional pilot study, 48 obese aged 8–12 years were enrolled from Dayton's Children Hospital, Ohio. Anthropometric, clinical biochemical assessments serum completed. Serum measured by UPLC-ESI-MS/MS. subset 23 children, parameters using calcaneal quantitative ultrasound (QUS). Results While exposure was consistent negative relationship parameters, among tested, only PFNA showed significant parameter (β [95% CI], = − 72.7 [− 126.0, 19.6], p .010). also raised systolic blood pressure (p .008), low density lipoprotein cholesterol (LDL-C; Conclusion may play skeletal cardiovascular risk profiles.