Hypothalamic Dysfunction and Neuroendocrine and Metabolic Alterations in Huntington Disease: Clinical Consequences and Therapeutic Implications

摘要: Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by cognitive, psychiatric, behavioural and motor disturbances. Although the course of HD also frequently complicated unintended weight loss, sleep disturbances autonomic nervous system dysfunction, aetiology these signs symptoms remains largely unknown. In recent years, many novel findings from both animal human studies have emerged that indicate considerable hypothalamic, endocrine metabolic alterations in HD. However, comprehensive overview lacking their precise clinical significance far clear. Therefore, this review we attempt to put developments field into perspective integrating them with previous comprehensible manner, discussing relevance, special focus on body weight, functions HD, which will allow for identification future lines research area.