Blood pressure control by drug group in the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)

摘要: Blood pressure (BP) control rates and number of antihypertensive medications were compared (average follow-up, 4.9 years) by randomized groups: chlorthalidone, 12.5–25 mg/d (n=15,255), amlodipine 2.5–10 mg/d (n=9048), or lisinopril 10–40 mg/d (n=9054) in a double-blind hypertension trial. Participants hypertensives aged 55 older with additional cardiovascular risk factor(s), recruited from 623 centers. Additional agents other classes added as needed to achieve BP control. was reduced 145/83 mm Hg (27% control) 134/76 mm (chlorthalidone, 68% control), 135/75 mm (amlodipine, 66% 136/76 mm (lisinopril, 61% 5 years; the mean drugs prescribed 1.9, 2.0, 2.1, respectively. Only 28% (chlorthalidone), 24% (amlodipine), (lisinopril) controlled on monotherapy. achieved majority each group—a greater proportion chlorthalidone. Over time, providers patients should expect multidrug therapy <140/90 mm patients.