Brønsted acid-catalyzed C-H Functionalisation of N-Protected Tetrahydroisoquinolines via Intermediate Peroxides
作者： Bertrand Schweitzer-Chaput , Martin Klussmann
关键词: Nucleophile 、 Homogeneous catalysis 、 Nitrogen atom 、 Organic chemistry 、 Brønsted–Lowry acid–base theory 、 Chemistry 、 Catalysis 、 Alkynylation 、 Surface modification
摘要: An organocatalytic oxidative synthesis of N-protected tetrahydroisoquinolines is described by C–H functionalization via intermediate peroxides. The peroxides were synthesized from tert-butylhydroperoxide under metal-free thermal conditions and converted into the final products Bronsted acid catalyzed substitution. nucleophile scope was investigated in detail proved to be broad; N-deprotection coupling could also achieved.
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