Oncologic Outcomes of Surgery Versus SBRT for Non-Small-Cell Lung Carcinoma: A Systematic Review and Meta-analysis.
作者： Michiel A. Ijsseldijk , Melina Shoni , Charles Siegert , Bastiaan Wiering , Anton K.C. van Engelenburg
DOI: 10.1016/J.CLLC.2020.04.017
关键词: Lung cancer 、 Radiology 、 Stereotactic body radiotherapy 、 Carcinoma 、 Variance method 、 Meta-analysis 、 Non small cell 、 Cohort study 、 Medicine 、 Lung
摘要: Abstract Background The optimal treatment of stage I non–small-cell lung carcinoma is subject to debate. aim this study was compare overall survival and oncologic outcomes lobar resection (LR), sublobar (SR), stereotactic body radiotherapy (SBRT). Methods A systematic review meta-analysis propensity matched comparative noncomparative cohort studies performed. Outcomes interest were disease-free survival. inverse variance method the random-effects for utilized assess pooled estimates. Results total 100 with patients treated clinical included. Long-term after LR superior over SBRT in all comparisons, most SR SBRT. Noncomparative showed long-term both Although papers heterogeneous low quality, results remained essentially same throughout a large number stratifications sensitivity analyses. Conclusion that has compared cI carcinoma. New trials are underway evaluating potentially operable patients.
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