Lung cancer in never smokers-the East Asian experience.

摘要: Approximately one third of all lung cancer patients in East Asia are never-smokers. Furthermore, the proportion never smokers (LCINS) has been increasing over time. Never-smokers more often diagnosed with adenocarcinoma Asia, a subtype largely defined by oncogenic drivers. In this subgroup patients, as high 90% have found to harbor well-known mutations and can be successfully managed targeted therapies inhibiting specific mutant kinases. EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment most important therapy from Asian never-smokers approximately 70% these opportunity receive EGFR-TKI treatment. Lung squamous cell carcinoma (SQCC) small (SCLC) two common histologic types smoking-related non-small (NSCLC). The SQCC SCLC seems higher than that Caucasian patients. Recent studies also suggest may distinct subtypes. Therefore, better understanding biologic characteristics subtypes provide new insights for review, we will an overview experience advanced, never-smoking cancer, focusing on etiologic factors development LCINS, adenocarcinoma, SCLC, role immunotherapy NSCLC.